Past Seminars

Here is the list of our past seminars:


Horacio Lopez Menendez. Biophysics seminar ESPCI-ENS - Olivia Du Roure, Viviane Fuchs

Mechanical Instabilities and their role on apoptotic cell extrusion

The balance between cell division and live or apoptotic cell extrusion states the tissue homeostasis. It has strong implications in developmental processes such as morphogenesis and pathological processes like tumor spreading. Previous works showed that apoptotic cell extrusion occurs by the formation of a contractile ring created either by the neighboring cells or by the apoptotic cell. It has been reported that cell elimination in crowded tissue via the activation of Caspase demands drastic changes.

The relationship between the structural remodeling during the apoptosis and the extrusion process is not clear. We show that apoptotic cell extrusion within epithelial tissues arises from two mechanical instabilities, namely delamination, driven by the osmotic pressure, and cavity formation, driven by the cytoskeleton gel rupture. We show that the mechanical instabilities can play a major role in the regulation of the cell extrusion. Finally, we develop theoretical models that capture the physical origin of these observations. Our approach provides mechanisms that can lead to efficient apoptotic homeostatic regulation in epithelial tissues.






Recent seminars  (0)


Horacio Lopez Menendez. Biophysics seminar ESPCI-ENS - Olivia Du Roure, Viviane Fuchs

Mechanical Instabilities and their role on apoptotic cell extrusion

The balance between cell division and live or apoptotic cell extrusion states the tissue homeostasis. It has strong implications in developmental processes such as morphogenesis and pathological processes like tumor spreading. Previous works showed that apoptotic cell extrusion occurs by the formation of a contractile ring created either by the neighboring cells or by the apoptotic cell. It has been reported that cell elimination in crowded tissue via the activation of Caspase demands drastic changes.

The relationship between the structural remodeling during the apoptosis and the extrusion process is not clear. We show that apoptotic cell extrusion within epithelial tissues arises from two mechanical instabilities, namely delamination, driven by the osmotic pressure, and cavity formation, driven by the cytoskeleton gel rupture. We show that the mechanical instabilities can play a major role in the regulation of the cell extrusion. Finally, we develop theoretical models that capture the physical origin of these observations. Our approach provides mechanisms that can lead to efficient apoptotic homeostatic regulation in epithelial tissues.






Seminar archive  (219)


Top



See also...

Practical Informations

Our weekly biophysics seminar is co-organized with colleagues at ENS and ESPCI. The audience is mainly composed of physicists with a deep (...) 

> More...

Register our newsletter

Justo grâvida vel facîlisis çurcus porta non dapidûs c’est dictumst sét vel pulvîar vulputate orci sét litoré, aliquet classé lacus facîlisis pérès £at (...) 

> More...