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Past Seminars

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Marina Elez (LJP, UPMC, Paris). Biophysics seminar ENS-ESPCI. - Clement Nizak, Olivia Du Roure

Mutation dynamics and fitness effects followed in single cells

Mutations have been investigated for more than a century but never witnessed in action in single cells, thus preventing direct characterization of their dynamics and reliable estimation of the distribution of their fitness effects. Such estimates have wide application and are critical for most evolutionary models/studies. We accomplished this in Escherichia coli by employing microfluidics, time-lapse imaging, and by visualizing mutations in single cells by using a fluorescent tag of the Mismatch Repair System. I will present our results obtained for strains having a wide range of mutation rates and growing under controlled condition in the absence of exogenous stress.






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Marina Elez (LJP, UPMC, Paris). Biophysics seminar ENS-ESPCI. - Clement Nizak, Olivia Du Roure

Mutation dynamics and fitness effects followed in single cells

Mutations have been investigated for more than a century but never witnessed in action in single cells, thus preventing direct characterization of their dynamics and reliable estimation of the distribution of their fitness effects. Such estimates have wide application and are critical for most evolutionary models/studies. We accomplished this in Escherichia coli by employing microfluidics, time-lapse imaging, and by visualizing mutations in single cells by using a fluorescent tag of the Mismatch Repair System. I will present our results obtained for strains having a wide range of mutation rates and growing under controlled condition in the absence of exogenous stress.






Archives des anciens séminaires  (219)


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This weekly seminar aims at gathering researcher form different thematics (physicists, biologists and chemists) and from different institutes in (...) 

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